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Jerry's Counts

"Caution" All Gleevec Patients, Please Read This!

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Jerry's Counts
Date WBC ANC Hgb Plts Dose Comments
11/13/03 10.0 7.70 14.6 274 15 mg
5 days/week		 Starting day of trial
11/17/03 8.8 5.19 14.3 238 15 mg
5 days/week		 Hydrea still keeping counts down.
Stopped Hydrea on 11/9/03
11/20/03 11.3 6.67 15.5 248 15 mg
5 days/week		 Hydrea beginning to wear off.
11/24/03 13.9 10.70 14.9 242 15 mg
5 days/week		 WBC up I expect a significant jump next week.
11/27/03 18.4 11.04 15.6 240 15 mg
5 days/week		 WBC up but not as much as I expected
12/01/03 14.2 9.09 14.7 358 15 mg
5 days/week		 WBC down, platelets up. Probably cycling.
Expect WBC up next time.
12/04/03 18.0 13.32 14.7 480 15 mg
5 days/week		 WBC up as it was last Thursday.
Platelets up.
12/08/03 12.1 8.59 14.4 554 15 mg
5 days/week		 WBC Down again after 4 days straight of the drug.
This could be a response see my diary. Platelets still rising.
12/11/03 21.3 12.57 15.3 597 15 mg
5 days/week		 Significant jump in WBC, Platelets up slightly.
12/15/03 19.4 8.92 15.3 497 15 mg
5 days/week		 WBC down slightly after 4 days on the drug. Platelets down some.
Talpaz thinks the drug is definitely affecting my counts, even at this low dose. This is good.
12/18/03 35.3 12.00 15.4 504 15 mg
5 days/week		 WBC Jumped 15,900 after 2 days off the drug.
Platelets about the same.
12/22/03 32.1 14.12 15.4 458 15 mg
5 days/week		 WBC down by 3,200 after 4 days on the drug (amazing at this low dose).
Platelets down a bit too.
12/25/03 44.2 22.98 16.0 430 15 mg
5 days/week		 WBC Jumped 12,100 after 2 days off the drug.
Platelets down in normal range.
12/29/03 39.0 19.89 15.0 414 15 mg
5 days/week		 WBC down by 5,200 after 4 days on the drug.
Platelets down a little more.
01/01/04 53.6 32.16 15.5 413 15 mg
5 days/week		 WBC Jumped 14,600 after 2 days off the drug.
Platelets in normal range.
01/05/04 44.3 25.25 15.3 401 15 mg
5 days/week		 WBC down by 9,300 after 4 days on the drug.
Platelets down a little more.
01/08/04 53.2 25.54 15.8 373 15 mg
5 days/week		 WBC Jumped 8,900 after 2 days off the drug.
Platelets slowly falling.
01/12/04 36.0 18.36 15.3 355 15 mg
5 days/week		 WBC down by 17,200 after 4 days on the drug.
Platelets down a little more.
01/15/04 41.9 25.14 15.4 341 30 mg
5 days/week		 WBC up 5,900 after 2 days off the drug.
I increased my dose to 30 mg. 5 days a week.
01/20/04 22.6 17.63 15.1 344 30 mg
5 days/week		 WBC down by 19,300 after 5 days at 30 mg. So far so good.
01/22/04 23.7 14.93 15.4 327 30 mg
5 days/week		 WBC up 1,100 after 2 days off the drug.
01/26/04 15.1 9.97 15.2 345 30 mg
5 days/week		 WBC down by 8,600 after 4 days at 30 mg.
01/29/02 16.4 10.50 15.0 334 30 mg
5 days/week		 WBC up by 1,300 after 2 days off the drug.
02/02/04 11.9 8.45 15.0 328 30 mg
5 days/week		 WBC down by 4,500 after 4 days at 30 mg.
02/05/04 10.8 7.45 15.5 307 30 mg
5 days/week		 WBC down 1,100 even after 2 days off the drug.
I am in hematological remission.
02/09/04 8.8 6.16 14.9 335 30 mg
5 days/week		 WBC down another 2,000 after 4 days at 30 mg.
02/12/04 10.9 7.96 15.4 351 30 mg
5 days/week		 WBC up 2,100 after 2 days off the drug.
02/16/04 8.4 6.13 15.4 366 30 mg
5 days/week		 WBC down 2,500 after 4 days at 30 mg. Platelets trending slightly up. My bone marrow may be in a slight "up- cycle". (Note: Bone marrow cycles sometimes producing more cells than other times.)
02/19/04 11.4 8.44 15.4 351 30 mg
5 days/week		 WBC up 3,000 after 2 days off the drug.
02/23/04 9.7 6.98 15.5 362 30 mg
5 days/week		 WBC down by 1,700 after 4 days at 30 mg.
02/26/04 10.8 7.45 15.6 350 30 mg
5 days/week		 WBC up 1,100 after 2 days off the drug.
03/01/04 11.0 8.47 15.2 369 30 mg
5 days/week		 WBC up by 200 after 4 days at 30 mg.
03/04/04 11.0 7.70 15.4 363 30 mg
5 days/week		 WBC unchanged after 2 days off the drug.
03/08/04 9.6 6.91 15.2 358 30 mg
5 days/week		 WBC down by 1,400 after 4 days at 30 mg.
03/11/04 12.5 9.00 15.6 357 30 mg
5 days/week		 WBC up 2,900 after 2 days off the drug.
03/15/04 10.3 7.72 16.0 385 30 mg
5 days/week		 WBC down by 2,200 after 4 days at 30 mg.
03/18/04 10.6 7.84 15.5 355 50 mg
5 days/week		 WBC up 300 after 2 days off the drug.
I increased my dose to 50 mg. 5 days a week.
03/22/04 8.7 6.61 15.5 357 50 mg
5 days/week		 WBC down by 1,900 after 4 days at 50 mg.
03/25/04 12.0 8.76 16.0 347 50 mg
5 days/week		 WBC up 3,000 after 2 days off the drug. I am starting to get a sinus infection.
03/27/04 18.6 17.48 14.9 348 50 mg
5 days/week		 WBC jumped due to a sinus infection. I got I.V. antibiotics at the Emergency Center today as well as 10 days of antibiotics to take after returning to my apartment.
03/29/04 10.2 7.96 15.5 321 50 mg
5 days/week		 The antibiotics must be working. My WBC has dropped significantly. I feel much better but not well yet.
04/01/04 12.0 9.00 15.5 345 50 mg
5 days/week		 WBC up 1800 after 2 days off the drug plus a sinus infection.
04/05/04 8.9 7.03 15.0 353 50 mg
5 days/week		 WBC down by 3,100 after 4 days at 50 mg. My sinus infection is much better.
04/08/04 9.2 6.72 15.8 307 50 mg
5 days/week		 WBC up 300 after 2 days off the drug. My sinus infection has cleared.
04/12/04 9.1 6.46 15.1 368 50 mg
5 days/week		 WBC down by 100 after 4 days at 50 mg.
04/15/04 8.1 5.83 15.6 339 50 mg
5 days/week		 WBC down 1,000 after 2 days off the drug.
04/19/04 6.7 4.62 15.2 303 50 mg
5 days/week		 WBC down by 1,400 after 4 days at 50 mg.
04/22/04 8.7 5.66 15.3 264 75 mg
5 days/week		 WBC up 2,000 after 2 days off the drug.
I increased my dose to 75 mg. 5 days a week.
04/26/04 7.3 5.55 15.4 289 75 mg
5 days/week		 WBC down by 1,400 after 4 days at 75 mg.
04/29/04 9.0 6.39 15.6 249 75 mg
5 days/week		 WBC up 1.700 after 2 days off the drug.
05/03/04 7.7 5.39 15.0 283 75 mg
5 days/week		 WBC down by 1,300 after 4 days at 75 mg.
05/06/04 9.5 6.65 15.8 224 75 mg
5 days/week		 WBC up 1.800 after 2 days off the drug.
05/10/04 7.2 4.97 15.6 258 75 mg
5 days/week		 WBC down by 2,300 after 4 days at 75 mg.
05/13/04 8.4 4.87 15.7 232 75 mg
5 days/week		 WBC up 1.200 after 2 days off the drug.
05/17/04 7.3 4.82 15.3 233 75 mg
5 days/week		 WBC down by 1,100 after 4 days at 75 mg.
05/20/04 9.0 5.76 16.1 239 75 mg
6 days/week		 WBC up 1.700 after 2 days off the drug.
Increased my days on the drug to 6 days a week.
I will take my first extra day Tuesday May 25.
05/24/04 7.4 4.74 15.1 249 75 mg
6 days/week		 WBC down by 1,600 after 4 days at 75 mg.
05/27/04 7.9 5.24 15.9 231 75 mg
6 days/week		 WBC up 500 after 1 day off the drug.
06/01/04 7.9 5.77 15.1 226 75 mg
6 days/week		 WBC unchanged after 5 days at 75 mg.
06/03/04 8.6 5.93 15.6 230 105 mg
6 days/week		 WBC up 700 after 1 day off the drug.
I increased my dose to 105 mg 6 days a week.
06/07/04 6.4 4.10 14.7 206 105 mg
6 days/week		 WBC down by 2,200 after 4 days at 105 mg.
06/10/04 5.4 4.27 14.8 212 105 mg
6 days/week		 WBC down 1000 after 1 day off the drug.
06/14/04 5.3 3.23 14.1 182 105 mg
6 days/week		 WBC down by 100 after 4 days at 105 mg.
06/17/04 4.7 3.38 14.1 195 105 mg
6 days/week		 WBC down 600 after 1 day off the drug.
06/21/04 4.3 2.58 13.6 170 105 mg
6 days/week		 WBC down by 400 after 4 days at 105 mg.
06/24/04 4.0 2.28 14.3 167 105 mg
6 days/week		 WBC down 300 after 1 day off the drug.
06/28/04 4.0 2.20 13.8 144 105 mg
6 days/week		 WBC unchanged after 4 days at 105 mg.
Platelets on the low end of normal.
07/01/04 3.2 2.34 13.7 146 105 mg
6 days/week		 WBC down 800 after 1 day off the drug.
07/05/04 4.0 1.92 13.6 138 105 mg
6 days/week		 WBC up 800 after 4 days at 105 mg.
07/08/04 4.6 2.76 14.6 124 105 mg
6 days/week		 WBC up 600 after 1 day off the drug.
07/12/04 3.0 1.71 12.5 120 105 mg
6 days/week		 WBC down 1600 after 4 days at 105 mg.
07/15/04 4.0 2.24 14.1 127 105 mg
6 days/week		 WBC up 1000 after 1 day off the drug.
07/19/04 3.6 1.69 13.3 134 105 mg
6 days/week		 WBC down 400 after 4 days at 105 mg.
I have a cytogenetic response...
I have 11 good cells out of 20...45% Ph+.
07/22/04 3.5 2.02 13.3 114 105 mg
6 days/week		 WBC down 100 after 1 day off the drug.
07/26/04 4.1 2.10 12.5 118 105 mg
6 days/week		 WBC up 600 after 4 days at 105 mg.
07/29/04 3.9 2.11 13.7 116 105 mg
6 days/week		 WBC down 200 after 1 day off the drug.
08/02/04 3.8 1.75 12.8 111 105 mg
6 days/week		 WBC down 100 after 4 days at 105 mg.
08/05/04 4.2 2.14 13.1 108 105 mg
6 days/week		 WBC up 400 after 1 day off the drug.
08/09/04 4.1 2.00 12.7 117 105 mg
6 days/week		 WBC down 100 after 4 days at 105 mg.
08/12/04 4.1 2.21 12.5 117 105 mg
7 days/week		 WBC unchanged after 1 day off the drug.
Increased my days on the drug to 7 days a week. I will take my first extra dose day Wednesday, August 18.
08/16/04 4.2 2.36 13.6 118 105 mg
7 days/week		 WBC up 100 after 4 days at 105 mg.
08/19/04 4.0 1.92 12.7 106 105 mg
7 days/week		 WBC down 200. Platelets slightly decreased
after starting 7 day dosing. Yesterday, (Wednesday) was the first Wednesday that I have taken the drug since starting the trial.
08/23/04 4.2 1.86 12.5 115 105 mg
7 days/week		 My counts are stable.
Dr. Talpaz is pleased, so am I.
08/26/04 4.0 1.96 12.5 96 105 mg
7 days/week		 Platelets decreased but not a problem.
08/30/04 3.7 2.00 12.3 96 105 mg
7 days/week		 Platelets Unchanged.
09/02/04 6.9 5.45 12.0 98 105 mg
7 days/week		 I have a severe sinus infection with 101.7 deg F fever.
I am taking 500 mg Levaquin daily (antibiotic).
09/06/04 4.9 2.94 12.7 98 105 mg
7 days/week		 My sinus infection is improved but not cleared.
I have 5 more days of the Levaquin to go.
09/13/04 4.8 2.46 12.6 95 105 mg
7 days/week		 My sinus infection is gone but I still have symptoms of a cold.
It must have been viral and not just a sinus infection.
09/20/04 4.9 2.50 12.4 95 105 mg
7 days/week		 What ever I had is much better although I am not back to 100%.
09/27/04 4.0 2.16 12.4 97 105 mg
7 days/week		 Everything is stable.
10/04/04 4.4 1.94 11.7 97 105 mg
7 days/week		 Hgb. down a little...Still no problems.
10/11/04 4.4 2.51 11.7 85 105 mg
7 days/week		 I had my 48 week BMB today.
I have a Major Cytogenetic Response.
16 Normal Cells Out of 20...20% Ph+
10/18/04 4.4 2.16 11.8 111 105 mg
7 days/week		 Everything is stable.
10/25/04 4.7 2.49 12.3 127 105 mg
7 days/week		 My counts are up slightly. Hopefully, this is a result of
the marrow being populated by normal cells.
11/01/04 4.0 2.08 12.6 123 105 mg
7 days/week		 Everything is stable.
11/08/04 4.3 2.38 11.9 114 105 mg
7 days/week		 Everything is stable.
11/15/04 4.4 2.64 12.9 143 105 mg
7 days/week		 CBC done in Columbia, Missouri.
11/22/04 4.1 2.21 12.6 127 105 mg
7 days/week		 Everything is stable.
11/29/04 4.9 2.74 12.7 136 105 mg
7 days/week		 Everything is stable.
12/06/04 4.1 2.21 12.2 106 105 mg
7 days/week		 Everything is stable.
12/10/04 4.3 2.40 12.2 118 105 mg
7 days/week		 Everything is stable.
12/13/04 4.6 2.71 12.8 158 105 mg
7 days/week		 Everything is stable.
12/20/04 4.1 1.93 13.2 140 105 mg
7 days/week		 Everything is stable.
12/27/04 3.7 2.22 13.0 140 105 mg
7 days/week		 Everything is stable.
01/03/05 5.4 3.05 12.8 158 105 mg
7 days/week		 I have a Complete Cytogenetic Response.
20 Normal Cells Out of 20...0% Ph+.
RT-PCR 2.5175%
01/10/05 4.1 3.20 12.7 159 105 mg
7 days/week		 Everything is stable.
01/17/05 4.1 2.26 13.6 143 105 mg
7 days/week		 Everything is stable.
01/24/05 4.1 2.02 14.2 142 105 mg
7 days/week		 Everything is stable.
01/31/05 4.2 2.50 13.9 167 105 mg
7 days/week		 Everything is stable.
02/07/05 4.4 2.87 13.2 149 105 mg
7 days/week		 Everything is stable.
02/14/05 4.3 2.51 13.5 155 105 mg
7 days/week		 Everything is stable.
02/21/05 4.9 3.17 13.6 169 105 mg
7 days/week		 Everything is stable.
02/28/05 5.1 3.03 14.0 185 105 mg
7 days/week		 Everything is stable.
RT-PCR 2.8900%...PCR not going down.
I will increase to 140 mg on 3/17/05
03/07/05 5.0 3.18 14.1 174 105 mg
7 days/week		 Everything is stable.
03/14/05 4.6 2.57 14.4 161 105 mg
7 days/week		 Everything is stable.
03/17/05 N/A N/A N/A N/A 140 mg
7 days/week		 No CBC Today...
Increased Dose to 140 mg
03/21/05 4.3 2.72 14.4 158 140 mg
7 days/week		 Everything is stable.
Cytogenetics 20/20 Normal Cells 0% Ph+
RT-PCR 5.6900%
03/28/05 5.6 3.47 14.5 163 140 mg
7 days/week		 Everything is stable.
04/04/05 4.1 2.47 14.2 157 140 mg
7 days/week		 Everything is stable.
04/11/05 4.9 2.90 14.3 175 140 mg
7 days/week		 Everything is stable.
RT-PCR 3.8700%
04/18/05 4.0 2.47 13.9 156 140 mg
7 days/week		 Everything is stable.
04/25/05 4.1 2.89 14.2 159 140 mg
7 days/week		 Everything is stable.
05/09/05 5.1 3.12 14.7 166 140 mg
7 days/week		 Everything is stable.
05/23/05 5.5 3.04 14.0 156 140 mg
7 days/week		 Everything is stable.
06/06/05 4.9 3.07 14.1 167 140 mg
7 days/week		 Everything is stable.
06/20/05 4.9 3.02 14.0 230 140 mg
7 days/week		 Everything is stable.
Cytogenetics 20/20 Normal Cells 0% Ph+
F.I.S.H. 200/200 Normal Cells
RT-PCR 1.2300%
06/27/05 4.6 2.76 13.5 178 140 mg
7 days/week		 Everything is stable.
7/14/05 4.1 2.48 14.6 175 140 mg
7 days/week		 Everything is stable.
08/02/05 4.3 2.67 13.4 172 140 mg
7 days/week		 Everything is stable.
08/15/05 4.2 2.34 13.5 171 140 mg
7 days/week		 Everything is stable.
09/12/05 4.8 2.92 14.0 214 140 mg
7 days/week		 Everything is stable.
Cytogenetics 20/20 Normal Cells 0% Ph+
F.I.S.H. 200/200 Normal Cells
RT-PCR 1.3700%
10/03/05 4.5 2.75 13.7 235 140 mg
7 days/week		 Everything is stable.
10/24/05 4.5 2.65 14.1 208 140 mg
7 days/week